ira tabas, phD
Dr. Tabas is the Richard J. Stock Professor of Medicine and Cell Biology at
Columbia University. His research focuses on (1) molecular-cellular mechanisms
of atherosclerosis, with an emphasis on endoplasmic reticulum (ER) stress and
inflammation in macrophages and dendritic cells; (2) pro-atherogenic roles of insulin
resistance and type 2 diabetes; and (3) calcium and ER stress signaling pathways
in hepatocytes that contribute to the metabolic disturbances of obesity and diabetes.
His most recent research on hepatocyte signaling has revealed novel drug targets for
type 2 diabetes.
He has lectured worldwide and published over 200 original research
articles and reviews. These papers have been published in Cell, Nature, Science,
Nature Cell Biology, Nature Reviews Immunology, Cell Metabolism, Journal
of Clinical Investigation, Proceedings of the National Academy of Sciences, and other
Dr. Tabas also serves on the Board of Reviewing Editors for the journal Science.
He was elected to both the Society for Clinical Investigation and the Association of
American Physicians. Dr. Tabas' other honors include the American Heart Association
Established Investigator Award, the Columbia University Doctor Harold and Golden
Lamport Research Award, the American Heart Association/ATVB Council Special
Recognition Award, the 2011 Alumni Achievement Award from Washington University
School of Medicine, and the 2014 Society of Leukocyte Biology Bonazinga award,
which is the society's highest honor for excellence in leukocyte biology research.
Lale Ozcan, Phd
Lale Ozcan is an Assistant Professor in the Department of Medicine at Columbia
University Medical Center and her work focuses on exploring novel signaling pathways
that control metabolic homeostasis. Lale joined the laboratory of Dr. Ira Tabas at
Columbia University in 2008 where she studied the detailed signaling pathways and
mechanisms underlying excessive glucose production and altered insulin signaling in
obesity. In addition to exploring signaling pathways, her work in Tabas lab also
uncovered new therapeutic opportunities in the context of insulin resistance.
Lale received her medical degree from Istanbul University Cerrahpasa School of
Medicine and did a postdoctoral work at Harvard University focusing on mechanisms
linking metabolic stress with insulin resistance and type 2 diabetes.